The Summary
In a comprehensive review spanning molecular geroscience to clinical trials, researchers evaluated emerging interventions and lifestyle habits aimed at slowing biological aging. While molecular therapies like senolytics, metformin, NAD+ boosters, and rapamycin show biological promise, none have proven to extend human lifespan. In contrast, foundational lifestyle practices—such as cardiorespiratory fitness, strength training, balanced nutrition, restorative sleep, and social connection—have robust, evidence-based track records for delaying chronic disease. Epigenetic clocks remain useful research tools, but the primary near-term clinical opportunity lies in compressing morbidity through everyday preventive health measures.
Why this is interesting
Anti-aging biotech often promises radical life extension through pills and epigenetic reprogramming, leading many to believe a miracle cure is imminent. However, this review grounds the hype in reality: no supplement or drug is currently proven to extend healthy human life. Instead, the most powerful tools are already within our control. Optimizing physical fitness, sleep, diet, and social bonds directly combats cellular decline and preserves vital function far better than any experimental compound. For everyday health, skipping unproven longevity fads in favor of rigorous, consistent lifestyle fundamentals remains the gold standard.