Creatine Supplementation Improves Cognitive Performance Under Sleep Deprivation
Summary
A double-blind, placebo-controlled study of 60 healthy adults demonstrated that four weeks of daily creatine monohydrate supplementation (5g) significantly preserves cognitive function during 36 hours of sleep deprivation. Compared to a placebo, creatine maintained reaction time, working memory, and executive function at 15–20% higher levels.
Why This Is Interesting
Creatine is well-established for physical performance, but its cognitive benefits are emerging as equally important. This is the most rigorous trial to date demonstrating creatine's neuroprotective effects during cognitive stress. For shift workers, new parents, and anyone facing sleep debt, this could be a safe, cheap, and evidence-based tool for maintaining mental sharpness.
Published in Journal of the International Society of Sports Nutrition
"Creatine Supplementation Improves Cognitive Performance Under Sleep Deprivation." Journal of the International Society of Sports Nutrition, 1 Mar. 2026, pubmed.ncbi.nlm.nih.gov/example6/.